When a protein in its native form, is subjected to physical change like change in temperature or chemical change like change in $\mathrm{pH}$, the hydrogen bonds get disturbed.
Due to this, globules unfold and helix gets uncoiled and protein loses its biological activity. This is called denaturation of proteins.
The coagulation of egg white on boiling and curdling of milk which is caused due to the formation of lactic acid by the bacteria present in the milk are two common examples of denaturation.